Herbal Treatment of Major Depression: Scientific Basis and Practical Use (Clinical Pharmacognosy Series)
Publisher: CRC Press
ISBN 10: 036737532X
ISBN 13: 978-0367375324
This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored.
- Focuses on oxidative damage, inflammation, and metabolic syndrome.
- Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications.
- These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act.
- The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.
Scott Mendelson, MD, PhD, has written a landmark volume in the Clinical Pharmacognosy series on Botanical Medicines for CRC Press. Why is this a landmark book? It thoughtfully reviews theories of the mechanisms of activity for antidepressants, including ketamine, and lays out the evidence for herbal activity through those mechanisms. Most psychiatrists will be surprised to learn about the anti-inflammatory, antioxidant, anti-diabetic, and neuroplastic effects of these herbs. Book chapters include relevant in vitro studies of the effects of 66 herbs, providing a foundation for understanding preclinical animal studies and human studies of depression. An additional chapter goes into detail about Chinese Herbal Medicine. Another chapter covers specific plant chemical constituents supported by data on their mechanisms of action. The final chapter discusses how to choose herbs, combine herbs, address comorbidities, and augment conventional synthetic pharmaceuticals. When you find that your patient is taking unfamiliar herbs for depression, this is the book to reach for. Here you will find the well-documented, clinically relevant information you will need to evaluate and advise your patient. This will also provide a sound basis for your entry into the realm of herbal prescribing to reduce adverse reactions, minimize the use of synthetic medications, augment other antidepressant treatments, and improve patient compliance and outcomes . . . I highly recommend this book for psychiatrists and other health professionals treating depression.
Richard P. Brown, M.D., Associate Professor of Clinical Psychiatry at Columbia University, Psychiatric Times, January, 2020
If you are a medical doctor, naturopathic physician, TCM practitioner or phytotherapist, this rare and scholarly work belongs in your hands. If you are looking for answers on how to self-treat with herbal medicines this will significantly shorten the time of trial and error to find the right remedy. The book is truly a great and valuable addition to the literature. Well done, Dr. Mendelson, and thanks for your insight, honesty and studious labor.
Kevin Spelman, PhD, MCPP, Founder and CEO of Health, Education & Research in Botanical Medicine
About the Author
Currently a practicing psychiatrist in Roseburg, Oregon, the author earned a Ph.D. in Biopsychology at The University of British Columbia, in Vancouver, British Columbia. He then worked for three years as a post-doctoral fellow at The Rockefeller University in the Laboratory of Neuroendocrinology under Bruce McEwen, Ph.D. During his doctoral work and as a post-doctoral fellow, he published 24 papers on the subjects of serotonergic and hormonal regulation of sexual behavior, and on the effects of stress on serotonin receptor subtypes in the brain. The author then attended medical school at The University of Illinois, and after graduating in 1996, he did his residency in psychiatry at The University of Virginia. In 2007, Elsevier published his first book, Metabolic Syndrome and Psychiatric Illness: Interactions, pathophysiology, assessment and treatment. In 2009, M. Evans published his second book, Beyond Alzheimer’s: How to avoid the modern epidemic of dementia